Influence of menopause and type 2 diabetes on pulmonary oxygen uptake kinetics and peak 2 exercise performance during cycling
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چکیده
TITLE 1 Influence of menopause and type 2 diabetes on pulmonary oxygen uptake kinetics and peak 2 exercise performance during cycling 3 AUTHORS 4 Catherine Kiely, Joel Rocha, Eamonn O’Connor, Donal O’Shea, Simon Green, Mikel 5 Egaña 6 AFFILIATIONS & ADDRESSES 7 1. School of Medicine, Department of Physiology, Trinity College Dublin, Dublin 2, 8 Ireland. 9 2. Endocrinology, St Columcille’s and St Vincent’s Hospitals, Dublin, Ireland. 10 3. School of Science and Health and School of Medicine, University of Western Sydney, 11 Sydney, Australia. 12 CONTACT INFORMATION (corresponding author): 13 Mikel Egaña 14 Department of Physiology, School of Medicine 15 Trinity College Dublin 16 Dublin 2, Ireland. 17 E-mail: [email protected] 18 Telephone: +353 1 896 1770 19 Fax: +353 1 679 3545 20 RUNNING HEAD: Menopause effects on VO2 kinetics in diabetes 21 22 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (August 12, 2015). doi:10.1152/ajpregu.00258.2015
منابع مشابه
Influence of menopause and Type 2 diabetes on pulmonary oxygen uptake kinetics and peak exercise performance during cycling.
We investigated if the magnitude of the Type 2 diabetes (T2D)-induced impairments in peak oxygen uptake (V̇O2) and V̇O2 kinetics was affected by menopausal status. Twenty-two women with T2D (8 premenopausal, 14 postmenopausal), and 22 nondiabetic (ND) women (11 premenopausal, 11 postmenopausal) matched by age (range = 30-59 yr) were recruited. Participants completed four bouts of constant-load cy...
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Nitric oxide (NO) synthase inhibition reduces leg glucose uptake during cycling without reducing leg blood flow (LBF) in young, healthy individuals. This study sought to determine the role of NO in glucose uptake during exercise in individuals with type 2 diabetes. Nine men with type 2 diabetes and nine control subjects matched for age, sex, peak pulmonary oxygen uptake (VO(2) peak), and weight...
متن کاملOlder type 2 diabetic males do not exhibit abnormal pulmonary oxygen uptake and muscle oxygen utilization dynamics during sub-maximal cycling exercise Running head: Oxygen uptake kinetics in older Type 2 diabetic patients
متن کامل
Older type 2 diabetic males do not exhibit abnormal pulmonary oxygen uptake and muscle oxygen utilization dynamics during submaximal cycling exercise.
There are reports of abnormal pulmonary oxygen uptake (Vo(2)) and deoxygenated hemoglobin ([HHb]) kinetics in individuals with Type 2 diabetes (T2D) below 50 yr of age with disease durations of <5 yr. We examined the Vo(2) and muscle [HHb] kinetics in 12 older T2D patients with extended disease durations (age: 65 ± 5 years; disease duration 9.3 ± 3.8 years) and 12 healthy age-matched control pa...
متن کاملSkeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes.
OBJECTIVE People with type 2 diabetes have impaired exercise responses even in the absence of cardiovascular complications. One key factor associated with the exercise intolerance is abnormally slowed oxygen uptake (VO2) kinetics during submaximal exercise. The mechanisms of this delayed adaptation during exercise are unclear but probably relate to impairments in skeletal muscle blood flow. Thi...
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